Peer-reviewed Publications
2023
2022
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Absolute quantification of cholesterol from thin tissue sections by silver-assisted laser desorption ionization mass spectrometry imaging Z.S. Nezhad*, J.P. Salazar*, R.S. Pryce*, L.M. Munter, and P. Chaurand*. Analytical and Bioanalytical Chemistry, Vol. 414, Iss. 23, 6947-6954 (2022)
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The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain and affects presenilin-mediated gene regulation F. Oestereich, N. Yousefpour, E. Yang*, A. Ribeiro-da-Silva, P. Chaurand*, L.M. Munter. Journal of Lipid Research, Vol. 63, Iss. 9 (2022)
2021
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Visualizing the distribution of strawberry plant metabolites at different maturity stages by MALDI-TOF imaging mass spectrometry J. Wang, E. Yang*, P. Chaurand*, V. Raghavan. Food Chemistry, Vol. 345 (2021)
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A matrix‐assisted laser desorption/ionization imaging mass spectrometric approach to study weight‐related changes within thyroid tissue A.A. Alfadda, H. Benabdelkamel, A.A. Fathaddin, I.O. Alanazi, N. Lauzon, P. Chaurand*, A. Masood. Journal of Mass Spectrometry, Vol. 56, e4671 (2021)
2020
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Probiotics Modulate a Novel Amphibian Skin Defense Peptide that is both Antifungal and Facilitates Growth of Antifungal Bacteria. D.C. Woodhams, L.A. Rollins-Smith, L.K. Reinert, B.A. Lam, R.N. Harris, C.J. Briggs, V.T. Vredenburg, B.T. Patel, R.M. Caprioli, P. Chaurand, P. Hunziker and L. Bigler. Microbial Ecology, Vol. 79, 192-202 (2020).
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Silver spray deposition for AgLDI imaging MS of cholesterol and other olefins on thin tissue sections E. Yang*, F. Fournelle* and P. Chaurand*. Journal of Mass Spectrometry, Special Issue, Vol. 55, e4428 (2020)
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Minimizing Visceral Fat Delocalization on Tissue Sections with Porous Aluminum Oxide Slides for Imaging Mass Spectrometry F. Fournelle*, E. Yang*, M. Dufresne* and P. Chaurand*. Analytical Chemistry, Vol. 92, 5158-5167 (2020)
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rMSIcleanup: an open-source tool for matrix-related peak annotation in mass spectrometry imaging and its application to silver-assisted laser desorption/ionization G. Baquer, L. Sementé, M. García-Altares, Y-J. Lee, P. Chaurand*, X. Correig and P. RàfolsJournal of Cheminformatics, Vol. 12, 45 (2020)
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Multimodal Imaging Mass Spectrometry to Identify Markers of Pulmonary Arterial Hypertension in Human Lung Tissue using MALDI-ToF, ToF-SIMS and Hybrid SIMS S. Van Nuffel, M. Quatredeniers, A. Pirkl, J. Zakel, J-P. Le Caer, N. Elie, Q. Vanbellingen, S. Dumas, M. Nakhleh, M. Ghigna, E. Fadel, M. Humbert, P. Chaurand*, D. Touboul, S. Cohen-Kaminsky and A. Brunelle. Analytical Chemistry, Vol. 92, 12079-12087 (2020)
2019
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Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver. D. Leclerc, K. Christensen, O. Cauv, E. Yang*, F. Fournelle*, R. Bahous, O. Malysheva, L. Deng, Q. Wu, Z. Zhou, Z.-H. Gao, P. Chaurand, M. A. Caudill and R. Rozen. Molecular Nutrition and Food Research, Vol 63, 1801001 (2019).
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Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis. H. Alarmi, N. H. Patterson, E. Yang*, P. Zoroquiain, A. Lazaris, P. Chaurand and P. Metrakos. Analytical and Bioanalytical Chemistry, Vol 411, 885-894 (2019).
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Enhancing ganglioside species detection for MALDI-TOF imaging mass spectrometry in negative reflectron mode. E. Yang*, M. Dufresne*, and P. Chaurand* International Journal of Mass Spectrometry, Vol. 437, 3-9 (2019).
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Co-registration and analysis of multiple imaging mass spectrometry datasets targeting different analytes. N.H. Patterson*, E. Yang*, E.-A. Kranjec* and P. Chaurand*. Bioinformatics, Vol. 35, 1261-1262 (2019).
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Mapping the fly Malpighian tubule lipidome by imaging mass spectrometry E. Yang*, C. Gamberi and P. Chaurand*. Journal of Mass Spectrometry, Vol. 54, 557-566 (2019).
2018
2017
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Multimodal detection of GM2 and GM3 lipid species in the brain of mucopolysaccharidosis type II mouse by serial imaging mass spectrometry and immunohistochemistry M. Dufresne*, D. Guneysu*, N.H. Patterson*, M.M. Marcinkiewicz, A. Regina, M. Demeule and P. Chaurand* Analytical and Bioanalytical Chemistry, Vol. 409, 1425-1433 (2017).
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Forensic analysis of latent fingermarks by silver-assisted LDI imaging MS on non-conductive surfaces. N. Lauzon*, M. Dufresne*, A. Beaudoin and P. Chaurand* Journal of Mass Spectrometry, Vol. 52, 397-404 (2017).
2016
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Surface Plasmon Resonance imaging - MALDI-TOF imaging mass spectrometry (SPRi - MALDI IMS) of thin tissue sections. S. Forest*, J. Breault-Turcot, P. Chaurand* and J-F. Masson. Analytical Chemistry, Vol. 88, 2072-2079 (2016).
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Three-dimensional imaging MS of lipids in atherosclerotic plaques: Open-source methods for reconstruction and analysis. N.H. Patterson*, R.J. Doonan, S.S. Daskalopoulou, M. Dufresne*, S. Lenglet, F. Montecucco, A. Thomas* and P. Chaurand*. Proteomics, Vol. 16, 1642-1651 (2016).
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Sodium-Doped Gold-Assisted Laser Desorption Ionization for Enhanced Imaging Mass Spectrometry of Triacylglycerols from Thin Tissue Sections. M. Dufresne*, J.-F. Masson and P. Chaurand* Analytical Chemistry, Vol. 88, 6018–6025 (2016).
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Assessment of pathological response to therapy using lipid mass spectrometry imaging. N.H. Patterson*, B. Alabdulkarim, A. Lazaris, A. Thomas*, M.M. Marcinkiewicz, Z. Gao, P.B. Vermeulen, P. Chaurand* and P. Metrakos. Scientific Reports, Vol. 6, 36814 (2016).
2015
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Increasing Specificity in Imaging Mass Spectrometry: High Spatial Fidelity Transfer of Proteins from Tissue Sections to Functionalized Surfaces. E. Fournaise* and P. Chaurand*. Analytical and Bioanalytical Chemistry, Vol. 407, 2159-2166 (2015).
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In Search of the Molecular Mechanisms Mediating the Inhibitory Effect of the GnRH Antagonist Degarelix on Human Prostate Cell Growth. M. Sakai, D.B Martinez-Arguelles, N.H Patterson*, P. Chaurand* and V. Papadopoulos. PLoS ONE, Vol. 10(3): e0120670 (2015).
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Development of Alternative Laser Desorption Imaging Mass Spectrometry Methods to Investigate the Molecular Composition of Latent Fingermarks. N. Lauzon*, M. Dufresne*, V. Chauhan and P. Chaurand*. Journal of the American Society for Mass Spectrometry, Vol. 26, 878-886 (2015).
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Acute Amnestic Encephalopathy in Amyloid-ß Oligomers Injected Mice is Due to Their Widespread Diffusion in Vivo. S. Epelbaum, I. Youssef, P.N. Lacor, P. Chaurand*, E. Duplus, B. Brugg, C. Duyckaerts and B. Delatour. Neurobiology of Aging, Vol. 36, 2043-2052 (2015).
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Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease. L.K. Hamilton, M. Dufresne*, S.E. Joppe, A. Aumont, S. Petryszyn, F. Calon, A. Furtos, M. Parent, P. Chaurand* and K.J.L. Fernandes. Cell Stem Cell, Vol. 17, 397-411 (2015).
2014
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Advances in Tissue Section Preparation for MALDI Imaging Mass Spectrometry. A. Thomas* and P. Chaurand*. Bioanalysis, Vol. 6, 967-982 (2014).
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Monitoring Time-dependent Degradation of Phospholipids in Sectioned Tissues by MALDI Imaging Mass Spectrometry. N.H. Patterson*, A. Thomas* and P. Chaurand*. Journal of Mass Spectrometry, Vol. 49, 622-627 (2014).
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Acyl-Coenzyme A Binding Protein Regulates Beta Oxidation Required for Growth and Survival of Non-Small Cell Lung Cancer. F.T. Harris, S.M.J. Rahman, M. Hassanein, J. Qian, M.D. Hoeksema, X. Ji, H. Chen, R. Eisenberg, P. Chaurand*, R.M. Caprioli, M. Shiota, and P.P. Massion. Cancer Prevention Research, Vol. 7, 748-757 (2014).
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Unravelling Nonspecific Adsorption of Complex Protein Mixture on Surfaces with SPR and MS. J. Breault-Turcot, P. Chaurand* and J-F. Masson. Analytical Chemistry, Vol. 86, 9612-9619 (2014).
2013
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Orthogonal Organic and Aqueous-based Washes of Tissue Sections to Enhance Protein Sensitivity by MALDI Imaging Mass Spectrometry. A. Thomas*, N.H. Patterson*, J. Laveaux Charbonneau* and P. Chaurand*. Journal of Mass Spectrometry, Vol. 48, 42-48 (2013).
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Histology-driven Data Mining of Lipid Signature from Multiple Imaging Mass Spectrometry Analyses: Application to Human Colorectal Cancer Liver Metastasis Biopsies. A. Thomas*, N.H. Patterson*, M. Marcinkiewicz, A. Lazaris, P. Metrakos and P. Chaurand*. Analytical Chemistry, Vol. 85, 2860-2866 (2013).
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Silver Assisted Laser Desorption Ionization for High Spatial Resolution Imaging Mass Spectrometry of Olefins from Thin Tissue Sections. M. Dufresne*, A. Thomas*, J. Breault-Turcot, J-F. Masson and P. Chaurand*. Analytical Chemistry, Vol. 85, 3318-3324 (2013).
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Nonspecific Adsorption of Crude Cell Lysate on SPR Sensors. A. Aube, J. Breault-Turcot, P. Chaurand*, J. Pelletier and J-F. Masson. Langmuir, Vol. 29, 10141-10148 (2013).
2012
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Sublimation of New Matrix Candidates for High Spatial Resolution Imaging Mass Spectrometry of Lipids: Enhanced Information in Both Positive and Negative Polarities After 1,5-diaminonapthalene Deposition. A. Thomas, J. Laveaux Charbonneau, E. Fournaise and P. Chaurand*. Analytical Chemistry, Vol. 84, 2048-2054 (2012).
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Activity-Based Probes linked with Laser-Cleavable Reporter Tags for Signal Amplification in Imaging Mass Spectrometry: Analysis of Serine Hydrolase Enzymes in Mammalian Tissue. J. Yang, P. Chaurand*, J.L. Norris, N.A. Porter and R.M. Caprioli. Analytical Chemistry, Vol. 84, 3689-3695 (2012).
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Imaging Mass Spectrometry of Thin Tissue Sections: A Decade of Collective Efforts. P. Chaurand*. Journal of Proteomics, Vol. 75, 4883-4892 (2012).
2011
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Advances in Proteomics Strategies Towards the Early Detection of Lung Cancer. M. Hassanein, S.M.J. Rahman, P. Chaurand* and P.P. Massion. Proceedings of the American Thoracic Society, Vol. 8, 183-188 (2011).
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Mass Spectrometry for the Evaluation of Cardiovascular Diseases Based on Proteomics and Lipidomics. A. Thomas*, S. Lenglet, P. Chaurand*, J. Deglon, P. Mangin, F. Mach, S. Steffens, J-L. Wolfender and C. Staub. Thrombosis & Haemostasis, Vol. 106, 20-33 (2011).
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Properties of Ionic Liquids on Au Surfaces: Non-conventional Anion Exchange Reactions with Carbonate. M. Ratel, M. Branca, J. Breault-Turcot, S.S. Zhao, P. Chaurand*, A.R. Shmitzer and J-F. Masson. Chemical Communications, Vol. 47, 10644-10646 (2011).
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MALDI Imaging Mass Spectrometry: A Promising Technique in Reproductive Research. M. Lagarrigue, R. Lavigne, B. Guevel, E. Com, P. Chaurand* and C. Pineau. Biology of Reproduction. Vol. 86(3)74, 1-11 (2011).